Table 2.
Regression coefficients for CVD risk factors in relation to change in log F2-IsoP or 15-F2t-IsoP-M (ng/mg Cr)
|
|
F2-IsoP
|
15-F2t-IsoP-M
|
||||||
|---|---|---|---|---|---|---|---|---|
|
|
Unadjusted
|
Adjusteda
|
Unadjusted
|
Adjusted*
|
||||
| β | P | β | p | B | p | β | p | |
| Systolic BP, per 20 mmHg
|
0.109
|
<0.001
|
0.019
|
0.524
|
0.169
|
<0.001
|
0.070
|
0.004
|
| Diastolic BP, per 10 mmHg†
|
0.100
|
<0.001
|
0.046
|
0.031
|
0.138
|
<0.001
|
0.072
|
<0.001
|
| BMI, per 5 kg/m2
|
0.092
|
<0.001
|
0.079
|
<0.001
|
0.121
|
<0.001
|
0.101
|
<0.001
|
| Waist circumference, per 5 cm‡
|
0.099
|
<0.001
|
0.080
|
<0.001
|
0.135
|
<0.001
|
0.109
|
<0.001
|
| Current smoking
|
0.169
|
0.006
|
0.122
|
0.046
|
0.216
|
<0.001
|
0.165
|
<0.001
|
| Type 2 diabetes
|
0.390
|
<0.001
|
0.249
|
0.009
|
0.326
|
<0.001
|
0.118
|
0.128
|
| Age, per 5 years
|
0.015
|
0.439
|
0.026
|
0.182
|
0.020
|
0.234
|
0.038
|
0.016
|
| 10-year CVD risk | 3.081 | <0.001 | 4.205 | <0.001 | ||||
*
Adjusted for systolic blood pressure, BMI, current smoking, prevalent diabetes, age
†
Adjusted for BMI, current smoking, prevalent diabetes, age
‡
Adjusted for systolic blood pressure, current smoking, prevalent diabetes, age Abbreviations: CVD, cardiovascular disease; F2-IsoP, F2-isoprostane; 15-F2t-IsoP-M, F2-isoprostane metabolite; BMI, body mass index; Cr, creatinine