Table 3.
Hazard ratios (HR) and 95% confidence intervals (CI) for incident diabetes and hypertension
| N events | N person-years | Unadjusted HR (95% CI) | Adjusted HR (95% CI)* | |
|---|---|---|---|---|
|
Diabetes
|
|
|
|
|
| F2-IsoP (ng/mg Cr)
|
|
|
|
|
| <1.38
|
14
|
3500.02
|
1
|
1
|
| 1.38+
|
23
|
3484.71
|
1.66 (0.85, 3.22)
|
1.14 (0.57, 2.29)
|
| Continuous (per ng/mg Cr)
|
|
|
1.22 (0.95, 1.58)
|
0.98 (0.73, 1.30)
|
| 15-F2t-IsoP-M (ng/mg Cr)
|
|
|
|
|
| <0.69
|
13
|
3550.93
|
1
|
1
|
| 0.69+
|
24
|
3433.81
|
1.91 (0.97, 3.75)
|
0.95 (0.45, 2.02)
|
| Continuous (per ng/mg Cr)
|
|
|
2.21 (1.24, 3.94)
|
1.01 (0.48, 2.10)
|
|
Hypertension
|
|
|
|
|
| F2-IsoP (ng/mg Cr)
|
|
|
|
|
| <1.00
|
20
|
1390.29
|
1
|
1
|
| 1.00-1.37
|
28
|
1443.45
|
1.37 (0.77, 2.44)
|
1.41 (0.79, 2.53)
|
| 1.38-1.94
|
29
|
1521.51
|
1.34 (0.76, 2.37)
|
1.19 (0.66, 2.14)
|
| 1.94+
|
37
|
1387.80
|
1.80 (1.04, 3.13)
|
1.31 (0.73, 2.35)
|
| Continuous (per ng/mg Cr)
|
|
|
1.23 (1.06, 1.43)
|
1.06 (0.90, 1.24)
|
| Ptrend
|
|
|
0.006
|
0.482
|
| 15-F2t-IsoP-M (ng/mg Cr)
|
|
|
|
|
| <0.53
|
14
|
1555.09
|
1
|
1
|
| 0.53-0.68
|
28
|
1510.49
|
2.07 (1.09, 3.93)
|
1.98 (1.04, 3.77)
|
| 0.69-0.93
|
33
|
1461.65
|
2.53 (1.36, 4.74)
|
2.34 (1.24, 4.43)
|
| 0.94+
|
39
|
1215.83
|
3.41 (1.85, 6.31)
|
2.34 (1.20, 4.56)
|
| Continuous (per ng/mg Cr)
|
|
|
2.33 (1.59, 3.40)
|
1.51 (0.98, 2.33)
|
| Ptrend | <0.001 | 0.060 |
*
Diabetes: adjusted for age, BMI, education, race, and physical activity; Hypertension: adjusted for age, BMI, education, race, physical activity, and current smoking
Abbreviations: F2-IsoP, F2-isoprostane; 15-F2t-IsoP-M, F2-isoprostane metabolite; Cr, creatinine