Table 3.
Factors Associated with Response
N | % Response | P | |
---|---|---|---|
Diagnosis | |||
Lymphoid malignancy | 13 | 38% | |
Myeloid malignancy | 23 | 48% | 0.59 |
Disease status at DLI | |||
No evidence of disease | 13 | 38% | |
Evidence of disease | 23 | 48% | 0.59 |
CD3 donor chimerism at DLI1 | |||
≤27% | 18 | 37% | |
>27% | 17 | 56% | 0.25 |
Time from HCT to study intervention | |||
<100 days | 21 | 57% | |
>100 days | 15 | 27% | 0.07 |
DLI dose | |||
1×107 CD3/kg | 26 | 54% | |
3×107 CD3/kg | 10 | 20% | 0.07 |
Donor | |||
Related | 17 | 47% | |
Unrelated | 19 | 42% | 0.77 |
Patient age at treatment intervention* | |||
≤56 years | 18 | 61% | |
>56 years | 18 | 28% | 0.04 |
Donor age at HCT* | |||
≤45 years | 17 | 41% | |
>45 years | 16 | 44% | 0.88 |
ANC count at DLI (×103/μL)* | |||
≤ 2.15 | 17 | 29% | |
>2.15 | 17 | 59% | 0.08 |
Lymphocyte count at DLI (×103/μL)* | |||
≤0.46 | 16 | 25% | |
>0.46 | 16 | 63% | 0.03 |
Immunosuppression after DLI | |||
No | 30 | 47% | |
Yes | 6 | 33% | 0.55 |
Divided at median