Table 1.
Characteristics of Pediatric Hematopoietic Cell Transplant Patients
| HCT Patients (n=85) | Matched Control Group* (n=340) | LRTI Comparison Group (n=308) | |||
|---|---|---|---|---|---|
| Demographics | |||||
| Age (median, IQR) * | 7.1 (3.7–13.4) | 7.9 (2.8–13.3) | p=0.969 | 1.2 (0.4–4.4) | p<0.001 |
| Female (n, %)* | 37 (43.5) | 148 (43.5) | p=1.000 | 144 (46.8) | p=0.598 |
| Race (n, %) | p=0.430 | p=0.365 | |||
| Black | 14 (16.5) | 73 (21.5) | 68 (22.1) | ||
| White | 48 (56.5) | 167 (49.1) | 149 (48.4) | ||
| Other/Unknown | 23 (27.1) | 100 (29.4) | 91 (29.6) | ||
| Ethnicity (n, %) | p=0.145 | p=0.158 | |||
| Hispanic/Latino | 11 (12.9) | 56 (16.5) | 53 (17.2) | ||
| Non-Hispanic/Latino | 56 (65.9) | 184 (54.1) | 167 (42.5) | ||
| Unknown | 18 (21.2) | 100 (29.4) | 88 (22.4) | ||
| PICU Admission Illness Severity | |||||
| PRISM (median, IQR) * | 5 (0–10) | 4.5 (0–9) | p=0.516 | 2 (0–5) | p<0.001 |
| Baseline Functional Status Scores (median, IQR) | |||||
| Functional Status Score | 7 (6–10) | 6 (6-6) | p<0.001 | 6 (6-6) | p<0.001 |
| Pediatric Overall Performance Category | 3 (2–3) | 1 (1-1) | p<0.001 | 1 (1-1) | p<0.001 |
| Pediatric Cerebral Performance Category | 1 (1–2) | 1 (1-1) | p<0.001 | 1 (1-1) | p<0.001 |
| Baseline Functional Status Class (n, %) | p<0.001 | p<0.001 | |||
| No/mild impairment (FSS score <10) | 60 (70.6) | 338 (99.4) | 303 (98.4) | ||
| Moderate/severe impairment (FSS score ≥10) | 25 (29.4) | 2 (0.6) | 5 (1.6) | ||
| PICU Supportive Care (n, %) | |||||
| At Least One Supportive Therapy | 47 (55.3) | 140 (41.2) | p=0.019 | 161 (52.3) | p=0.621 |
| Mechanical Ventilation | 31 (36.5) | 125 (36.8) | p=0.956 | 154 (50) | p=0.027 |
| Renal Replacement Therapy | 5 (5.9) | 8 (2.4) | p=0.148 | 5 (1.6) | p=0.043 |
| Vasoactive Infusions | 30 (35.3) | 74 (21.8) | p=0.010 | 57 (18.5) | p=0.001 |
Legend: Functional status represents pre-hospital baseline.
*
Patients in the matched control group were matched 4:1 to HCT patients on age, sex, and PRISM score.