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. 2018 Jan 10;8:1945. doi: 10.3389/fimmu.2017.01945

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Copyright © 2018 Wang and Cardell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Yin and Yang of invariant natural killer T (iNKT) cells in tumor immunity. iNKT cells can either suppress T helper 1 (TH1) tumor immunity and promote an immunosurveillance environment as found in intestinal polyposis (Yin, left) (PLZF-neg; PLZF-negative), or enhance TH1 immunity to tumors as found in many tumor models and inferred from studies of human cancer (Yang, right).