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Competition radioligand binding. Equilibrium radioligand binding was performed with [3H]-α-BTX (1 nM) in human kidney tsA201 cells expressing α7 nAChRs. A-867744 (3 nM to 30 μM) caused no significant displacement of [3H]-α-BTX binding, whereas the orthosteric antagonist MLA caused complete displacement of specific radioligand binding. Data points are means of triplicate samples (±S.E.M.) from a single experiment, and data are typical of three independent experiments.
