Fig. 9.

Docking of A-867744, TBS-516, and TQS and into α7 structural models. After docking studies with the closed and open models (top and bottom panels, respectively), representatives of binding mode clusters are illustrated for A-867744 (A and D; purple). TBS-516 (B and E; orange), and TQS (C and F; cyan). Amino acids that are discussed in the text are shown in stick representation. Predicted hydrogen bonds are shown with dashed lines. In each case, the principal subunit is shown in khaki (on the left in each panel) and the complimentary subunit is shown in olive (on the right in each panel).