Figure 1. Proteome signature remodelling in HIT and HIT+β₂A.

Effect of 4 weeks of high intensity training with (HIT+β₂A, n = 12) and without (HIT, n = 9) daily inhalation of terbutaline (4 mg day⁻¹) on proteome signature of the vastus lateralis muscle in trained men. A–C, volcano plots of within‐group changes in skeletal muscle proteins (486 proteins) in HIT (A) and HIT+β₂A (B), as well as between‐group interaction (HIT+β₂A – HIT) (C). Green scale indicates % false discovery rate (FDR). D, Gaussian fit of frequency distribution of discriminant canonical function score of within‐group changes in proteome signature using principal component‐discriminant analysis (PCA‐DA) of the eight first principal components that explained 70% of total proteome variance. E–G, enrichment analysis of the 10 most up‐ (blue) and downregulated (red) pathways (GO: biological processes, GO: cellular component, and KEGG pathways) in HIT (E) and HIT+β₂A (F) as well as between‐group (HIT+β₂A – HIT) (G).