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. 2017 Dec 15;40(1):e12506. doi: 10.1111/pim.12506

Table 3.

Associations between antibody (IgE and IgG4) levels and Kato‐Katz positivity (S. mansoni), SPT reactivity and reported wheeze

Geometric meana
Antigen Antibody/antibody ratio SmKK− SmKK+ aGMR (95% CI)b, c P value
SWA IgE 1080 2433 1.54 (1.28, 1.84) <.001
IgG4 4031 27 355 3.71 (3.14, 4.37) <.001
SEA IgE 1412 1833 1.32 (1.15, 1.52) <.001
IgG4 18 962 241 763 5.51 (4.55, 6.67) <.001
House dust mite IgE 0.782 10.678 1.25 (1.07, 1.45) .006
IgG4 0.001 0.192 1.79 (1.51, 2.13) <.001
IgG4/IgE ratio 0.002 0.033 1.18 (0.58, 2.41) .629
Cockroach IgE 18.8 19.2 1.00 (0.82, 1.22) .989
IgG4 0.002 0.292 1.50 (1.34, 1.68) <.001
IgG4/IgE ratio 0.001 0.027 1.32 (0.94, 1.85) .110
Total IgE 969 3073 1.37 (1.22, 1.54) <.001
Total IgG4 51 453 233 745 1.94 (1.49, 2.52) <.001
Total IgG4/total IgE ratio 52.16 75.24 1.36 (1.11, 1.67) .005
Total IgE/cockroach IgE ratio 3.79 12.60 1.32 (1.06, 1.66) .014
Total IgE/dust mite IgE ratio 0.562 1.301 1.13 (1.02, 1.25) .016
Cockroach SPT− Cockroach SPT+
SWA IgE 1704 1894 1.12 (0.94, 1.32) .173
IgG4 12 860 14 155 1.04 (0.85, 1.28) .675
SEA IgE 1611 1876 1.12 (0.97, 1.29) .092
IgG4 84 831 101 778 1.08 (0.92, 1.27) .319
Dust mite IgE 2.6 42.2 1.59 (1.35, 1.89) <.001
IgG4 0.022 0.061 1.06 (0.87, 1.29) .498
IgG4/IgE ratio 0.009 0.001 0.56 (0.36, 0.85) .010
Cockroach IgE 18.9 39.1 1.25 (1.08, 1.46) .004
IgG4 0.054 0.686 1.15 (0.95, 1.39) .129
IgG4/IgE ratio 0.003 0.017 0.69 (0.47, 1.02) .064
Total IgE 1462 2787 1.22 (1.05, 1.42) .011
Total IgG4 90 643 126 688 0.84 (0.65, 1.07) .163
Total IgG4/total IgE ratio 60.41 45.80 0.75 (0.58, 0.95) .022
Total IgE/cockroach IgE ratio 6.07 9.22 1.01 (0.82, 1.25) .894
Total IgE/dust mite IgE ratio 0.849 0.868 0.93 (0.84, 1.03) .140
Dust mite SPT− Dust mite SPT+
SWA IgE 1667 2409 1.26 (1.00, 1.57) .043
IgG4 13 088 12 565 1.04 (0.79, 1.36) .744
SEA IgE 1623 1887 1.23 (0.99, 1.53) .055
IgG4 85 471 102 026 1.20 (0.85, 1.68) .271
Dust mite IgE 2.5 242.9 2.10 (1.57, 2.81) <.001
IgG4 0.020 0.245 1.41 (0.99, 1.99) .052
IgG4/IgE ratio 0.009 0.001 0.49 (0.23, 1.04) .064
Cockroach IgE 19.9 33.7 1.21 (1.03, 1.43) .024
IgG4 0.065 0.405 1.13 (0.85, 1.50) .395
IgG4/IgE ratio 0.004 0.013 0.71 (0.48, 1.04) .075
Total IgE 1533 2802 1.24 (1.03, 1.49) .025
Total IgG4 89 885 156 204 1.09 (0.86, 1.38) .438
Total IgG4/total IgE ratio 57.43 55.45 0.89 (0.72, 1.11) .292
Total IgE/cockroach IgE ratio 6.41 8.11 1.01 (0.82, 1.26) .893
Total IgE/dust mite IgE ratio 0.937 0.517 0.81 (0.74, 0.89) <.001
No wheeze Wheeze
SWA IgE 1672 2627 1.15 (0.81, 1.64) .425
IgG4 12 753 14 802 1.05 (0.71, 1.54) .808
SEA IgE 1636 1547 0.93 (0.66, 1.29) .662
IgG4 81 698 145 978 1.16 (0.77, 1.73) .449
House dust mite IgE 2.8 26.6 1.35 (0.89, 2.04) .148
IgG4 0.007 0.008 0.85 (0.59, 1.25) .407
IgG4/IgE ratio 0.011 0.001 0.45 (0.22, 0.93) .032
Cockroach IgE 21.2 2.9 0.69 (0.55, 0.87) .003
IgG4 0.021 0.006 0.65 (0.53, 0.82) .001
IgG4/IgE ratio 0.004 0.002 1.14 (0.47, 2.74) .760
Total IgE 1630 1522 0.88 (0.72, 1.07) .205
Total IgG4 100 983 74 475 0.85 (0.61, 1.17) .302
Total IgG4/total IgE ratio 61.00 47.36 0.95 (0.77, 1.18) .683
Total IgE/cockroach IgE ratio 6.29 6.86 0.91 (0.78, 1.05) .187
Total IgE/dust mite IgE ratio 0.857 0.752 0.91 (0.77, 1.05) .188

SWA, Schistosoma worm antigen; SEA, Schistosoma egg antigen; SmKK−, Kato‐Katz negative result (S. mansoni), single stool sample; SmKK+, Kato‐Katz positive result, single stool sample; aGMR, adjusted geometric mean ratio; 95% CI, 95% confidence interval. P values ≤0.05 are highlighted in bold.

a

All antibody concentrations in ng/mL.

b

All geometric mean ratios and 95% confidence intervals adjusted for survey design, age and sex.

c

Geometric mean ratios and 95% confidence intervals for associations between antibody levels and SPT reactivity and wheeze were additionally adjusted for SmKK result.