Table 2.
Termination rates determined from reviewed studies and the audits reported here compared to pre‐NIPT termination rates
| Citation | Termination Ratea | Country | Pre‐NIPT Termination Rate for DSb (year(s) obtained) |
|---|---|---|---|
| Lau et al26, 27 | 100%c | Hong Kong | Not found |
| Pettit et al28 | 63% | United States | 67% (1995‐2011)41 |
| Vahanian et al29 | 0% | United States | 67% (1995‐2011)41 |
| Shaw et al30 | 100%c | Taiwan | 68% (2001)45 |
| Beamon et al31 | 60% | United States | 67% (1995‐2011)41 |
| Tiller et al8 | 40% | United States | 67% (1995‐2011)41 |
| Song et al32 | 67% | China | 94% (2003‐2011)24 |
| Dobson et al33 |
Singletons: 64% Twins: 40% |
United States | 67% (1995‐2011)41 |
| Oepkes et al34 | 86%c | The Netherlands | 93% (2010)44 |
| Chitty et al35 |
NIPT: 70% IPD: 93% Overall: 79% |
United Kingdom | 92% (2007‐2008)21 |
| Gil et al36, 37 |
NIPT:44% IPD: 93% Overall: 73% |
United Kingdom | 92% (2007‐2008)21 |
| Gil et al38 | 100%c | Spain | 96%d (2002‐2004)46 |
| Qiang et al40 | 87% | China | 94% (2003‐2011)24 |
| Le Conte et al39 | 100%c | France | 96%e (2002‐2004)46 |
| Reported here |
NIPT: 67% IPD: 93% Overall: 88% |
Singapore | Not found |
| Reported here | 62.7% | United Kingdom | 92% (2007‐2008)21 |
Termination rate calculated as a proportion of all pregnancies that had a high‐risk result for DS from NIPT (false positives and negatives excluded).
Termination rate calculated as a proportion of all pregnancies that had a definitive prenatal diagnosis of DS by IPD.
All high‐risk results from NIPT were confirmed by IPD.
Termination rate for EUROCAT (European Surveillance of Congenital Anomalies) registry regions of Spain (Barcelona, Basque, Asturias, and Madrid).
Termination rate for EUROCAT (European Surveillance of Congenital Anomalies) registry regions of France (Auvergne, Paris, Central East and Strasbourg).
Abbreviations: DS, Down syndrome; IPD, invasive prenatal diagnosis; NIPT, noninvasive prenatal testing.