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. 2017 Nov 20;293(2):412–432. doi: 10.1074/jbc.M117.807032

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Figure 6. — The comparative transcriptomic profile of CDR6/ROA1 null mutant NKKY101. A, the genes with ≥2-fold change are annotated on the basis of biological processes using CGD Go-slim mapper. The x axis indicates the biological functional categories, and the y axis indicates the number of genes. Left column, categories of genes that are only up-regulated; middle column, categories of genes that are up- and down-regulated; right column, the categories of genes that are only down-regulated. B, interaction map of the CDR6/ROA1 null mutant NKKY101 using five major categories from up- and down-regulated genes. Clustering was based on gene involvement in biological functions using Cytoscape software. Red and green circles, genes down- and up-regulating, respectively. The size of the circle is proportional to -fold change (the higher the -fold change, the bigger the size of the circle).