Figure 3.

Cardiac mitochondrial cardiolipin acyl chains are remodeled in response to a Western diet in the absence and presence of EPA and DHA. Heat maps of major (A), intermediate (B), and minor (C) CL acyl chains for mice consuming a control (CON), Western diet (WD), WD + EPA, and WD + DHA are shown. D, monolyso-CL species in cardiac mitochondria are also shown. Data are the average from five independent experiments. Asterisks indicate significance from control (*, p < 0.05). Daggers indicate significance relative to the WD (†, p < 0.05), and hash tags indicate significance between EPA and DHA at 14 or 4 weeks (#, p < 0.05). For simplicity, statistical significance is not indicated between time points (14 and 4 weeks).