Table 1. Results from Paraben Derivative Synthesis and Antimicrobial Screening against S. aureus.

X, Y, Z	ROH	compd	rxn time (h)	rxn yield (%)	S. aureus MIC μg/mL (μM)
F, F, F	BuOH	2a	18	35	128 (483)
Cl, Cl, H	BuOH	2b	18	65	64 (245)
Br, Br, H	BuOH	2c	18	53	32 (91)
Br, H, H	BuOH	2d	18	66	64 (236)
I, I, H	BuOH	2e	1	75	16 (36)
I, H, H	BuOH	2f	18	42	64 (199)
CH3, CH3, H	BuOH	2g	18	70	>256a (>1045)
tBu, tBu, H	BuOH	2h	18	67	>256a (834)
OH, OH, H	BuOH	2i	18	50	512 (2055)
OMe, OMe, H	BuOH	2j	18	88	>256a (924)
NO2, NO2, H	BuOH	2k	3	56	512 (1809)
I, I, H	OctOH	3e	1	59	16 (31.8)
CH3, CH3, H	OctOH	3g	18	71	64 (213)
OH, OH, H	OctOH	3i	18	40	64 (210)
NO2, NO2, H	OctOH	3k	18	82	16 (47)
butyl parabenb					256 (1320)
penicillin G					0.25 (0.749)

^aNot soluble at the higher 512 μg/mL concentration and therefore was not tested.

^bEquivalent to butyl ester (2) with X, Y, Z = H, H, H.