Table 2. IC₅₀s for Paraben Binding to ERα as Determined by TR-FRET Analysis.

X, Y, Z	compd	IC50 (nM)
F, F, F	2a	29400
Cl, Cl, H	2b	55300
Br, Br, H	2c	39400
Br, H, H	2d	8210
I, I, H	2e	34600
I, H, H	2f	7980
CH3, CH3, H	2g	32500
tBu, tBu, H	2h	>200000
OH, OH, H	2i	8970
OMe, OMe, H	2j	>200000
NO2, NO2, H	2k	>200000
I, I, H	3e	13200
CH3, CH3, H	3g	16200
OH, OH, H	3i	8740
NO2, NO2, H	3k	60400
H, H, H	butyl paraben	1420
	17-β-estradiol	0.452