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. 2017 Dec 13;9(1):28–33. doi: 10.1021/acsmedchemlett.7b00395

Table 1. SAR of Indane Substitution.

graphic file with name ml-2017-00395x_0006.jpg

compd *stereochemistry R1 R2 p300 HAT IC50 (μM)
4 R,S H H 1.6
9 R,S CN H 2.5
10 R,S H CN 27.8
11 R,S CONH2 H 4.86
12 R,S H CONH2 17.9
13 R,S OMe H 1.6
14 R,S CH2 OH H 14.0
15 R,S cyclopropyl H 1.71
16 R,S NHCOMe H 0.78
17 S NHCO2-Me H 1.0
18 S NHSO2-Me H 16.0
19 S NHCONH-Me H 0.24