Table 3. Pharmacokinetic Properties of 24 (A-485).
| mouse | rat | dog | |
|---|---|---|---|
| CLp (L/h/kg) | 0.56 | 1.23 | 0.09 |
| CLp,u (L/h/kg) | 75 | 47 | 4.4 |
| t1/2 (h) | 0.7 | 1.2 | 7 |
| Vss (L/kg) | 0.5 | 1.5 | 0.8 |
| F (%) | 110 | 63 | 74 |
| Fa × Fg30 | 1 | 0.93 | 0.78 |
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