Table 4.
Effect of curcumin and quercetin on Cyp and Del-induced changes in lipid peroxidation, non- enzymatic and enzymatic antioxidants
| Parameter | Group A | Group B | Group C | Group D | Group E | Group F | Group G |
|---|---|---|---|---|---|---|---|
| LPO (nmoles MDA/hours/gtissue) | 3.165 ± 0.2749 | 7.68 ± 0.166q** | 5.726 ± 0.148r** | 9.145 ± 0.489** | 7.725 ± 0.319q* * | 7.2 ± 0.402r** | 4.675 ± 0.309r* |
| GSH(µmole/g tissue) | 2.920 ± 0.288 | 1.735 ± 1.145r** | 1.986 ± 0.224r** | 0.706 ± 0.071** | 1.566 ± 0.03827r** | 1.323 ± 0.0388q** | 2.725 ± 0.1385r• |
| SOD (nmole/minutes/mg protein) | 31.911 ± 1.262 | 17.648 ± 1.631r** | 22.858 ± 1.474r** | 10.631 ± 0.5518** | 21.726 ± 0.9145r** | 19.453 ± 1.170r** | 28.874 ± 0.7624r• |
| CAT(µ mole/minutes/mg protein) | 74.14 ± 1.193 | 47.62 ± 1.335r** | 60.596 ± 1.295r** | 36.538 ± 1.331** | 69.521 ± 0.659r* | 69.123 ± 0.620r* | 72.00 ± 0.7857r• |
| GPx (nmole/minutes/mg protein) | 8.396 ± 1.005 | 5.346 ± 0.715q* | 6.613 ± 0.774q• | 3.728 ± 0.760** | 6.531 ± 0.771q• | 6.083 ± 0.736q• | 8.073 ± 0.719r• |
| GR (nmole/minutes/mg | 3.553 ± 0.339 | 2.418 ± 0.250q* | 2.808 ± 0.2778r• | 1.366 ± 0.1686** | 2.635 ± 0.185r* | 2.566 ± 0.2008r* | 3.326 ± 0.1578r• |
| GST (µmole/minutes/mg protein) | 91.015 ± 0.681 | 84.471 ± 1.141r** | 86.823 ± 0.775r* | 74.973 ± 1.284** | 78.153 ± 0.673p** | 77.906 ± 0.741p** | 83.038 ± 0.791r** |
Data are presented as mean ± SEM of 6 rats in each group.
Cyp; Cypermethrin, Del; Deltamethrin, •; P>0.05, *; P<0.05, **; P<0.01 compared with group A, p; P>0.05, q; P<0.05, r; P<0.01 compared with group D, Group A; Control, B; Cyp, C; Del, D; Cyp+Del, E; Cyp+Del+curcumin, F; Cyp+Del+quercetin, and G; Cyp+Del+curcumin+quercetin.