Fig. 4.
DPH corrects CORT-induced deficiencies in dendrite arborization. (a) Experimental timeline indicating CORT and DPH administration periods and sample collection time point. (b) Representative neurons. (c) Mice were exposed to 21 days of CORT, with either DPH or its vehicle introduced at day 11. CORT decreased arbor length as expected, but DPH blocked this loss. As in our initial studies, apical arbors were unaffected. (d) Sholl analyses revealed that chronic CORT again decreased basal branch intersections, but DPH intervention corrected this deficiency. Bars = means + SEMs, *p < 0.05 vs. control; #p < 0.05 vs. CORT +DPH. n = 16–22 neurons/group; 6–9 mice/group.