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Erlotinib causes chromatin condensation, karyopyknosis and upregulated apoptosis proteins dose-dependently in L-02 cells when L-02 cells were exposed to increasing doses of erlotinib for 48 h. (A) Fluorescence microscopic images of the nuclear morphology of L-02 cells, stained with DAPI. (B) The upregulation of c-caspase-3 and c-PARP analyzed by western blotting. Data are representative of three independent experiments. ERLO, erlotinib; c-, cleaved; PARP, poly (ADP-ribose) polymerase.
