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Ang1/Tie2 activated the PI3K/Akt pathway in PTC. The expression of PI3K, Akt, p-Akt detected by western blotting and reverse transcription-quantitative polymerase chain reaction in PTC cells transfected with pcDNA3.1-Ang1 and Tie2 shRNA. *P<0.01 vs. the control group. Ang1, angiopoietin 1; shRNA, short hairpin RNA; shTie2, shRNA targeted at Ang receptor; PI3K, phosphoinositide-3 kinase; p-Akt, phosphorylated RAC serine/threonine-protein kinase; PTC, papillary thyroid carcinoma.
