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. 2017 Nov 1;15(1):152–158. doi: 10.3892/etm.2017.5416

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effects of NBP on the mRNA expression levels of IFN-γ, RORγt and Foxp3 in muscle tissue of EAM guinea pigs. The relative mRNA (housekeeping gene GAPDH) expression of (A) IFN-γ, (B) RORγt and (C) Foxp3 were determined in skeletal muscle tissue samples from EAM guinea pigs. Saline represents the EAM/saline vehicle injection group, low NBP represents the low-dose (40 µl/40 mg/kg wt) NBP group, and high NBP represents the high-dose (80 µl/80 mg/kg wt) NBP group. Values are expressed as the mean ± standard deviation (n=10 per group). *P<0.05, **P<0.01 vs. saline group. EAM, experimental autoimmune myositis; NBP, 3-n-butylphthalide; IFN-γ, interferon-γ; RORγt, retinoic acid receptor-related orphan nuclear receptor γt; Foxp3, forkhead box p3.