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. 2018 Jan 11;13:367–386. doi: 10.2147/IJN.S144266

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© 2018 Jahan et al. This work is published and licensed by Dove Medical Press Limited

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Effect of OV/OV-MP NPs for cytokine secretion from mature DCs.

Notes: Untreated DC was used as negative control. LPS treated DCs were positive control. After 24 hour incubation, DC culture supernatants were analyzed for IFNγ (A, B), IL-12 (C, D), IL-6 (E, F), and TNF-α (G, H) secretion. This figure is representative for 0.18 iv COOH-, 0.55 iv COOH-, 0.15 ester-, and 0.55 ester-terminated plain and anti-CD205-tailored NPs (n=3; p<0.05).

Abbreviations: AD, adsorption; C, COOH; COV, covalent binding; DC, dendritic cell; E, ester; IFNγ, interferon-γ; IL, interleukin; iv, inherent viscosity; LPS, lipopolysaccharide; MP, monophosphoryl lipid A; NPs, nanoparticles; OV, ovalbumin; TNF, tumor necrosis factor.

Effect of OV/OV-MP NPs for cytokine secretion from mature DCs.

Notes: Untreated DC was used as negative control. LPS treated DCs were positive control. After 24 hour incubation, DC culture supernatants were analyzed for IFNγ (A, B), IL-12 (C, D), IL-6 (E, F), and TNF-α (G, H) secretion. This figure is representative for 0.18 iv COOH-, 0.55 iv COOH-, 0.15 ester-, and 0.55 ester-terminated plain and anti-CD205-tailored NPs (n=3; p<0.05).

Abbreviations: AD, adsorption; C, COOH; COV, covalent binding; DC, dendritic cell; E, ester; IFNγ, interferon-γ; IL, interleukin; iv, inherent viscosity; LPS, lipopolysaccharide; MP, monophosphoryl lipid A; NPs, nanoparticles; OV, ovalbumin; TNF, tumor necrosis factor.