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. 2018 Jan 11;12:137–148. doi: 10.2147/DDDT.S148457

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© 2018 Han et al. This work is published and licensed by Dove Medical Press Limited

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GPR30 knockdown eliminated IP-induced PI3K/AKT pathway activation of hPDLCs. The siRNA transfection efficiency of hPDLCs was tested by using the positive control with fluorescence. (A) Western blot (B) and PCR (C) results of GPR30 knockdown of hPDLCs. The expression of AKT and p-AKT was assessed by Western blot. (D) Quantitative analysis of Western blot band from (D) was performed. (E) *P<0.05, ***P<0.001. Magnification ×200.

Abbreviations: IP, ipriflavone; siRNA, small interfering RNA; hPDLCs, human periodontal ligament cells; PCR, polymerase chain reaction; NC, negative control; siGPR30, siRNA targeting GPR30 mRNA.