Table 1.
Genotype and allele frequencies of PTPN22 variants in patients with psoriasis and matched healthy controls.
| Genotype/allele | Psoriasis (n = 106) |
Control (n = 200) |
P value | RR | EFa/PF |
|---|---|---|---|---|---|
| No. (%) | No. (%) | ||||
| CC | 67 (63.21) | 185 (92.50) | <.001b,* | 0.139 | 0.622 |
| CT | 39 (36.79) | 15 (7.50) | <.001b,* | 7.151 | 0.621a |
| TT | 0 (0) | 0 (0) | — | — | — |
| C allele | 173 (81.60) | 385 (96.25) | <.001b,* | 0.173 | 0.597 |
| T allele | 39 (18.40) | 15 (3.75) | <.001b,* | 5.764 | 0.596a |
Abbreviations: EF, etiologic fraction; PF, preventive fraction; RR, relative risk.
Number of allele/genotype is represented as No. (%).
a
Data for EF.
b
Statistically significant using Fisher exact test.
*
P < .004—Bonferroni corrected.