Table 3.

Dose Recommendations for Bisphosphonates⁴²,⁴³,⁴⁵,⁵⁶,⁴⁸,⁴⁹

Bisphosphonate	Prophylactic Dose	Treatment Dose	CrCl Recommendation
Alendronate	5 mg PO once daily or 35 mg PO once weekly	10 mg PO once daily or 70 mg PO once weekly	≥ 35 mL/min
Risedronate (IR)	5 mg PO once daily or 35 mg once weekly	5 mg PO once daily or 35 mg PO once weekly or 150 mg PO once monthly	≥ 30 mL/min
Zoledronic acid	5 mg IV every 2 years	5 mg IV once yearly	≥ 35 mL/min
Ibandronate	2.5 mg PO once daily or 150 mg PO once monthly	2.5 mg PO once daily or 150 mg PO once monthly or 3 mg IV every 3 months	≥ 30 mL/min

CrCl = creatinine clearance; IR = immediate release; IV = intravenous; PO = orally.