Table 4.

AWPs of Selected Osteoporosis Medications¹¹⁰

Compound	Generic/Brand	Dosing Strength	Route	Dosing Frequency	AWP Range*
Bisphosphonates
Alendronate	Generic	5 mg, 10 mg	PO	Daily	$87.68–$87.80
		35 mg, 70 mg		Weekly	$4.26–$82.52
Risedronate	Generic	150 mg	PO	Monthly	$223.80–$318.58
		5 mg		Daily	$265.67
		35 mg		Weekly	$247.80–$247.81
	Atelvia (Allergan)	35 mg (DR)		Weekly	$304.93
	Generic	35 mg (DR)		Weekly	$209.21–$209.22
Ibandronate	Generic	150 mg	PO	Monthly	$17.00–$168.40
		1 mg/mL 3 mL vial	IV	Every 3 months	$500.00–$505.20 (every 3 months)
	Boniva (Genentech)	150 mg	PO	Monthly	$229.14
	Boniva (IV) (Genentech)	1 mg/mL 3 mL vial	IV	Every 3 months	$632.88 (every 3 months)
Zoledronic acid	Generic	5 mg/mL 100 mL vial	IV	Yearly	$270.00–$1,004.42 (per year)
	Reclast (Novartis)	5 mg/mL 100 mL vial		Yearly	$1,300.60 (per year)
RANKL Inhibitor
Denosumab	Prolia (Amgen)	60 mg/mL 1 mL syringe	SC	Every 6 months	$1,353.84 (every 6 months)
Estrogen Agonist/Antagonists
Raloxifene	Generic	60 mg	PO	Daily	$192.22–$213.84
	Evista (Eli Lilly)	60 mg		Daily	$198.00
Conjugated estrogens/bazedoxifene	Duavee (Pfizer)	0.45 mg/20 mg		Daily	$202.04
Parathyroid Hormone Analogues
Teriparatide	Forteo (Eli Lilly)	250 mcg/mL 2.4 mL pen	SC	20 mcg daily	$3,953.64
Abaloparatide	Tymlos (Radius Health)	2,000 mcg/mL 1.56 mL pen		80 mcg daily	$1,950.00
Calcitonin-Salmon
Calcitonin-salmon	Generic	200 IU/ actuation 3.7 mL	IN	1 spray daily	$118.54
	Miacalcin (Novartis)	200 IU/mL	SC	100 IU daily	$21,921.52

^*One-month supply unless otherwise specified.

AWP = average wholesale price; DR = delayed release; IN = intranasal; IV = intravenous; PO = oral; RANKL = receptor activator of nuclear factor kappa-B ligand; SC = subcutaneous.