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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: J Psychopharmacol. 2017 Jan 16;31(7):812–818. doi: 10.1177/0269881116684338

Figure 1. Pharmacological approaches that target ethanol metabolism via ALDH inhibition.

Figure 1

Non selective irreversible inhibition of ALDH (disulfiram) produces aversive side-effects. Selective ALDH2 reversible inhibition (ALDH2i) has been shown to prevent the increase of alcohol-induced rewarding dopamine release in brain, reduce cocaine-induced euphoria and inhibit anxiety-like behaviors.