Skip to main content
. 2017 Dec 9;8(69):113472–113493. doi: 10.18632/oncotarget.23052

Figure 4. Inhibition of PTTG1 expression impairs invasiveness of melanoma cells sensitive or resistant to dabrafenib.

Figure 4

A375 and A375R cells (A) as well as SK-Mel28 and SK-Mel28R cells (B) were transiently transfected with siPTTG1 or siCTRL and 24 h later incubated with 100 nM dabrafenib (DAB) or DMSO alone. After 48 h of culture, the cells were assayed for ECM invasion. Data are expressed in terms of percentage of invaded cells with respect to siCTRL/A375 or siCTRL/SK-Mel28 cells treated with DMSO. Each value represents the arithmetic mean ± SEM of four (A375 and A375R) or three (SK-Mel28 and SK-Mel28R) independent experiments. **P < 0.01 siCTRL/DAB vs siCTRL/DMSO; ##P < 0.01 siPTTG1/DAB vs siPTTG1/DMSO; §§P < 0.01 siPTTG1/DMSO vs siCTRL/DMSO; ^^P < 0.01 siPTTG1/DMSO vs siCTRL/DAB; ††P < 0.01 siPTTG1/DAB vs siCTRL/DAB.