Table 1. Correlation between clinicopathologic feature of patients and intensity of ARF6, NEDD9 and MT1-MMP.
Clinical Parameters | Cores (%) | |||||||
---|---|---|---|---|---|---|---|---|
Tissues | Grade | Age (y) | Tumor | Cores | Staining | ARF6 | NEDD9 | MT1-MMP |
Normal | NA | 37–72 | NA | 23 | Low (1–2) | 94.34 ± 0.11 | 95.45 ± 0.21 | 97.40 ± 0.21 |
High (3–4) | 5.66 ± 0.18 | 4.55 ± 0.11 | 3.59 ± 0.27 | |||||
Malignant | Gr .I | 36–57 | T1. T2 | 60 | Low (1–2) | 25.56 ± 0.21 | 17.45 ± 0.32 | 20.23 ± 0.21 |
High (3–4) | 74.44 ± 0.19 | 82.55 ± 0.19 | 79.77 ± 0.32 | |||||
Gr .II | 29–84 | T1. T2 | 120 | Low (1–2) | 14.98 ± 0.22 | 10.56 ± 0.24 | 15.07 ± 0.27 | |
High (3–4) | 85.02 ± 0.15 | 89.03 ± 0.11 | 84.93 ± 0.19 | |||||
Gr. III | 45–80 | T1. T2 T3. T4 | 34 | Low (1–2) | 10.78 ± 0.12 | 9.65 ± 0.13 | 11.30 ± 0.45 | |
High (3–4) | 89.22 ± 0.22 | 90.44 ± 0.18 | 88.68 ± 0.36 |
NOTE: Grade I, indicates well differentiated; Grade II, moderately differentiated; Grade III, poorly differentiated; T1, indicates tumor invades submucosa; T2, tumor invades muscularis propria; T3, tumor invades through muscularis propria into subserosa or into nonperitonealized pericolic or perirectal tissues; T4, tumor directly invades other organs or sturtures and/or perforate. Staining intensity: 0, no staining; 1, weak; 2, moderate; 3, strong. The percentage of cells expressing elevated levels of ARF6, NEDD9 and MT-MMP was high in endometrial tumors compared to normal endometrium. Statistically significant (p < 0.05) values are given in bold.