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. 2017 Nov 20;8(69):113701–113718. doi: 10.18632/oncotarget.22555

Figure 3. Knockdown of XIST reduces tumor volume in nude mouse xenograft model.

Figure 3

(A) Nude mouse xenograft model was generated. The lentivirus containing LV-sh-contr or LV-sh-XIST was injected into tumor after 5 days of PANC-1 cells injection, and the tumor volume changes on day 5, 10, 15, 20, 25 and 30 were determined in response to XIST knockdown. (B) Tumor volume in nude mice. (C) Tumor weight in nude mice. (D and E) The protein levels of CDK1, Cyclin D1 and P21 in xenograft tumors were determine by using Western blot assays. The data are shown as mean± SD of three independent experiments. *P<0.05, **P<0.01.