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. 2017 Dec 6;8(69):113837–113846. doi: 10.18632/oncotarget.22985

Figure 4. Overexpression of miR-489 enhanced the anti-tumor effect of 5-FU in vivo.

Figure 4

(A) T-47D cells were infected with lentivirus with miR-489 and subcutaneously injected into BALB/c nude mice (8 mice for each group). Expression of miR-489 in lentivirus-infected tumors was detected by using qRT-PCR analysis. *P < 0.05 vs. empty lentivirus group, #P < 0.05 vs. 5-FU + empty lentivirus group. (B) Tumor growth in nude mice was inhibited by co-treatment with miR-489 and 5-FU (5 mg/kg 5-FU every three days) . (C) 5-FU-induced enrichment of CSCs was suppressed by miR-489 overexpression in tumors. *P < 0.05 vs. empty lentivirus group, #P < 0.05 vs. 5-FU + empty lentivirus group.