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. 2017 Dec 6;8(69):113837–113846. doi: 10.18632/oncotarget.22985

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Copyright: © 2017 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Putative binding site of miR-489 in the XIAP 3’-UTR predicted by online bioinformatics database of TargetScan. (B) Upregulation of XIAP in T-47D and SKBR3 CSCs compared to their non-CSCs. (C) Overexpression of miR-489 in breast cancer cells decreased the expression of XIAP in vivo. (D) Overexpression of miR-489 in breast cancer cells decreased the expression of XIAP in vitro. (E) Transfection with miR-489 decreased the luciferase activities of the pGL3 reporter with XIAP 3’-UTR. ^*P < 0.05.