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. 2017 Dec 5;8(69):113847–113857. doi: 10.18632/oncotarget.22943

Figure 3. LKB1 loss cooperating with BRAF V600E mutation promotes the migration and invasion behavior of melanoma cell lines.

Figure 3

A375 cells were transiently transfected with SiLKB1 and SiCtrl respectively and performed further test 3 days after transfection. (A) Cell migration assay was performed according to the methods described above. A375 cells transfected with SiLKB1 showed a faster wound closure rate than the cells transfected with SiCtrl. (B) Cell invasion assay was performed according to the methods described above. LKB1 knockdown significantly enhanced invasion of A375 cells. Data are obtained from 3 independent experiments and shown as means±SD of triplicate experiments(** p>0.05).