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. 2017 Dec 7;8(69):114002–114018. doi: 10.18632/oncotarget.23113

Figure 6. FIH1 deSUMOylation is impaired in PE leading to decreased FIH1 levels.

Figure 6

(A) Representative Western Blots for FIH1 in preeclamptic placentae (PE) and in normotensive age-matched controls (AMC), and respective densitometric analysis (right panel) p < 0.01 (n = 6 AMC, n = 7 PE). (B) Immunofluorescence analysis of FIH1 (red) and SUMO2/3 (green) in in PE and AMC placental tissue. Nuclei were counterstained with DAPI (blue). White bars represent 25 µm. (C) Representative Western Blots for SENP3 and FIH1 after FIH1 immunoprecipitation in PE (n = 9) and AMC (n = 9) tissue. (D) Representative Western Blots for RNF4 and FIH1 after FIH1 immunoprecipitation in PE and AMC tissue.