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. 2017 Dec 15;8(69):114300–114313. doi: 10.18632/oncotarget.23259

Figure 7. Sirt6 mRNA-mediated protective effects are independent of Sirt1.

Figure 7

(A) Sirt1 siRNA abrogates Sirt1 mRNA expression in HUVECs. (B) Adv-Sirt6-treated EMPs increase Sirt6 mRNA levels in Sirt1 KD HUVECs. (C) Adv-Sirt6-treated EMPs protect against high glucose-induced IL-10 decreases and TNF-a and IL-1b increases in Sirt1 KD HUVECs. (D) Adv-Sirt6-treated EMPs protect against high glucose-induced NO decreases in Sirt1 KD HUVECs. CT, control; HG, high glucose; EMPs, endothelial microparticles. * p<0.05 vs CT; # p<0.05 vs HG. GAPDH mRNA serves as an internal control.