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. 2018 Jan 9;13:293–305. doi: 10.2147/IJN.S152485

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Specific targeting of prostate cancer cells with hybrid ELP/liposome nanoparticles.

Notes: Lipids were used to generate various types of DTX-encapsulating liposomes, which were mixed with recombinant ELPs to form self-assembled nanoparticles at raised temperature. The use of ELP-GRP fusion proteins increased specific binding to GRPR expressing prostate cancer cells and showed enhanced cytotoxic effects.

Abbreviations: DTX, docetaxel; ELP, elastin-like polypeptide; GRP, gastrin-releasing peptide; GRPR, gastrin-releasing peptide receptor.