Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 9;13:293–305. doi: 10.2147/IJN.S152485

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Flow cytometric analysis of cell targeting with ELP and ELP/liposome nanoparticles.

Notes: GRP displaying formulations are shown in blue, particles without GRP are shown in red, and controls (cells without treatment) are shown in gray. The arbitrarily set fluorescence cutoff is indicated with a red arrow head. (A) Binding of 1.5× ELP-GRP/K-Atto and 1.5× ELP-C/K-Atto to PC-3 cells. (B) Binding of DTX-loaded hybrid nanoparticles, 1.5× ELP-GRP/K-Atto/ACD-1/DTX and 1.5× ELP-C/K-Atto/ACD-1/DTX, to PC-3 cells. Panels (C and D) show flow cytometric analysis of DU-145 cells treated with the same formulations as described above for panels A and B, respectively. Panels (E and F) show control experiments carried out with GRPR-negative 293T cells using similar protocols as described above.

Abbreviations: DTX, docetaxel; ELP, elastin-like polypeptide; GRP, gastrin-releasing peptide; GRPR, gastrin-releasing peptide receptor.