Table 8.2.

Cell-surface and post-entry alpha-herpesvirus triggers

	Trigger	Sensor	Event
Internal transformation of virion architecture	Heparan sulfates	gC	Release of the pUL16 tegument protein from the capsid. Possibly the cause of capsid displacement with the virion to an eccentric position.
Fusion based entry	Nectin HVEM Modified heparin sulfates	gD	Fusion of envelope with cell membrane deposits capsid and tegument into the cytosol.
Tegument release	Phosphorylation Reduction Proteases	Likely multiple tegument proteins	Solubilizes outer tegument components and exposes the capsid and inner tegument proteins.
Genome injection	Nups Proteases	Likely VP1/2 tegument protein and pUL25 capsid protein	VP1/2 is cleaved and genome is delivered through nuclear pores following release from the capsid.