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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Pharm Sci. 2017 Oct 16;107(2):513–528. doi: 10.1016/j.xphs.2017.10.012

Table 3.

Characteristics of 5-FU-loaded magnetic PLGA nanoparticles from previous studies

Fabrication
method		 PLA:PGA
ratio		 Organic
phase		 Surfactant Mean
diameter
(nm)		 Encapsulation
efficiency (%)		 Loaded
drug
amount
(mg/mg)		 Release
duration
(days)		 Route
of
injection		 Reference
Multiple emulsion-solvent evaporation 50:50 DCM PVA 90.7–316.6 83.4 0.043 25 - 86
Multiple emulsion-solvent evaporation 50:50 DCM Glycerin, span 60 67.2 63.8 0.073 35 IV 87
Emulsion-solvent evaporation - Aceto-nitrile Span 80 800 - 0.20 - PT 187
Nanoprecipitation - Liquid paraffin, aceto-nitrile Span 80 200–1500 - - - - 131

Abbreviations: SC – subcutaneous; IV – intravenous; DCM – dichloromethane; PLA – polylactic acid; PGA – polyglycolic acid; PT – peritumoral