Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Clin Immunol. 2017 Jul 15;189:43–51. doi: 10.1016/j.clim.2017.07.006

FIGURE 2.

FIGURE 2

This figure exemplifies in practical fashion the neuroimmune structure underlying the phenomenology known as the brain’s immune privilege. Injection of an adenovirus expressing influenza hemagglutinin (HA) into the brain parenchyma does not cause a systemic anti-adenoviral, or anti-HA immune response. However, if the same virus is injected into the brain ventricles or subcutaneously a systemic immune response against HA can be detected. As a negative control, injection into the ventricles of a virus not expressing HA, does not cause systemic anti-HA immunity.