Table 1.
Patient characteristics
| Characteristic | Total (n = 259) | EGFR MT (n = 73) | EGFR WT (n = 186) | p value |
|---|---|---|---|---|
| Sex | ||||
| Male | 167 (64.5) | 27 (37.0) | 140 (75.3) | < 0.001 |
| Female | 92 (35.5) | 46 (63.0) | 46 (24.7) | |
| Age, yr | 68 (37–89) | 66 (37–87) | 68 (37–89) | 0.155 |
| Smoking history | < 0.001 | |||
| Never-smoker | 106 (40.9) | 48 (65.8) | 58 (31.2) | |
| Former smoker | 68 (26.3) | 15 (20.5) | 53 (28.5) | |
| Current smoker | 85 (32.8) | 10 (13.7) | 75 (40.3) | |
| Pathologic histology | < 0.001 | |||
| Adenocarcinoma | 180 (70.0) | 64 (87.7) | 116 (62.4) | |
| Squamous | 40 (15.4) | 2 (2.7) | 38 (20.4) | |
| Large cell | 27 (10.4) | 6 (8.2) | 21 (11.3) | |
| Other | 12 (4.6) | 1 (1.4) | 11 (5.9) | |
| Type of EGFR mutation | ||||
| Deletion in exon 19 | 41 (56.2) | |||
| L858R | 23 (31.5) | |||
| Others | 9 (12.3) | |||
| Brain metastases | 67 (25.9) | 27 (37.0) | 40 (21.5) | < 0.006 |
| Synchronous BM | 20 (27.4) | 27 (14.5) | < 0.009 | |
| Metachronous BM | 7 (9.6) | 13 (7.0) | < 0.578 |
Values are presented as number (%) or median (range).
EGFR, epidermal growth factor receptor; MT, mutation type; WT, wild type; BM, brain metastasis.