Table 3.

A 2 × 2 ANCOVA analysis for the gray matter volume difference between TTH and migraine

MNI coordinates			Cluster size	Anatomical region	Local peak T/F-value
x	y	z
Headache type effect (TTH > migraine)
-27	−38	−39	705	L cerebellum VI	4.57
5	−74	50	380	R precuneus cortex	4.38
-24	8	65	611	L superior frontal gyrus	4.23
3	−87	−26	590	R cerebellum crus II	4.03
32	−17	6	1839	R putamen	3.81
32	−33	−33	340	R cerebellum V	3.75
34	18	59	324	R middle frontal gyrus	3.55
-29	−20	3	1128	L putamen	3.55
17	13	8	638	R caudate	3.45
Headache frequency effect (Episodic > Chronic)
14	45	15	933	R anterior cingulate cortex	3.96
-47	17	0	1070	L insula	3.87
-6	−57	−2	366	L cerebellum V	3.78
36	29	7	364	R insula	3.54
Type × frequency interaction effect
29	−72	24	530	R lateral occipital cortex	14.04
Post-hoc comparisons
Episodic TTH > Episodic migraine
26	14	1	1850	R putamen	4.21
3	−86	−21	542	R cerebellum crus I	3.91
41	26	51	573	R middle frontal Gyrus	3.91
-29	−18	0	1131	L putamen	3.87
9	12	14	364	R caudate	3.30
Episodic TTH < episodic migraine
42	−78	−12	535	R lateral occipital cortex	−3.55
Chronic TTH > Chronic migraine
-27	−41	−38	640	L cerebellum VI	3.67
Chronic TTH < Chronic migraine: non-significant

Abbreviations: L left, MNI Montreal Neurological Institute, N.S. non-significant, R right, TTH tension-type headache