Table 1.
Fractional anisotropy (FA) measures (arbitrary values).e
| Brain region | CONT |
ID |
P-value |
|||||
|---|---|---|---|---|---|---|---|---|
| PND 32 | PND 61 | PND 32 | PND 61 | SEM | Diet | Day | Diet × day | |
| Caudate | 0.340 | 0.344 | 0.327 | 0.339 | 0.00454 | 0.04 | 0.06 | 0.37 |
| Cerebellum | 0.192 | 0.211 | 0.178 | 0.199 | 0.00397 | <0.01 | <0.001 | 0.79 |
| Corpus callosum | 0.299 | 0.334 | 0.292 | 0.327 | 0.00440 | 0.16 | <0.001 | 0.85 |
| Internal capsule | 0.433 | 0.456 | 0.421 | 0.450 | 0.00356 | 0.04 | <0.001 | 0.21 |
| Left cortex | 0.321b | 0.341d | 0.317a | 0.333c | 0.00144 | <0.01 | <0.001 | 0.03 |
| Left hippocampus | 0.304 | 0.301 | 0.306 | 0.298 | 0.00515 | 0.91 | 0.19 | 0.43 |
| Right cortex | 0.333a,b | 0.347c | 0.330a | 0.337b | 0.00234 | 0.01 | <0.001 | 0.05 |
| Right hippocampus | 0.300 | 0.302 | 0.292 | 0.305 | 0.00569 | 0.69 | 0.13 | 0.25 |
| Thalamus | 0.319 | 0.321 | 0.311 | 0.315 | 0.00542 | 0.14 | 0.58 | 0.87 |
| Whole brain (from FA)f | 0.317a | 0.340c | 0.315a | 0.328b | 0.00146 | <0.001 | <0.001 | <0.001 |
| Whole brain (from T1 scan)g | 0.319a | 0.339c | 0.316a | 0.329b | 0.00148 | <0.01 | <0.001 | 0.01 |
CONT, control; ID, iron deficient; PND, postnatal day; FA, fractional anisotropy.
a,b,c,dMeans in a row without a common superscript letter differ, P < 0.05.
eData presented as mean and pooled standard error of the means (SEM) for each dietary treatment group. Main effects of dietary treatment (Diet; CONT vs ID) and postnatal MRI day (Day; PND 32 vs 61) and the interaction between Diet and Day are presented.
fWhole brain FA values were generated from FA diffusion masks with a threshold of 0.15 to ensure only white matter was measured.
gWhole brain FA values were generated from T1-weighted white matter segmentation that was applied to the diffusion data.