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. 2018 Jan 11;4:248. doi: 10.3389/fmed.2017.00248

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Copyright © 2018 Reisz, Tzounakas, Nemkov, Voulgaridou, Papassideri, Kriebardis, D’Alessandro and Antonelou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multivariate analysis of metabolic phenotypes of stored red blood cells (RBCs) from glucose 6-phosphate dehydrogenase (G6PD)-deficient donors. Partial least square discriminant analysis [PLS-DA—panel (A)] revealed a U-shaped distribution of packed RBC samples from G6PD-deficient donors over storage in the blood bank, consistent with previous reports from Palsson’s lab (29, 30) and our group (9, 31). A loading plot for most significant variables informing the PLS-DA discrimination is shown in panel (B), and includes bioactive lipids and bile acids. In panel (C), a heat map of time course metabolic changes in RBCs from G6PD sufficient (median) or deficient (n = 6) donors, divided by pathway as specified by color codes in the top right corner of the panel.