Figure 9.

Network analysis of donors’ variables at time of donation that had significant correlations with the redox status of the packed red blood cells (RBCs) regardless of the storage duration. The sub-network consists of 62 connections involving intracellular reactive oxygen species (ROS) accumulation, antioxidant capacity of the supernatant, DHA, and other variables. In-bag DHA and ROS levels at post-storage-mimicking conditions represented the most important hub nods. Plasma uric acid and its attributed antioxidant capacity revealed their “intra-parameter” dynamics (see also Figure 7). Continuous black lines: positive correlations; dashed red lines: negative correlations.