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. 2018 Jan 11;10:454. doi: 10.3389/fnmol.2017.00454

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Copyright © 2018 Li, Cao, Li, Huang, Li and Abumaria.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression and profiling of mRNA in LH vs. Ctrl and LH vs. NLH comparisons. (A,B) Scatter plotting of the global mRNA expression pattern in the LH vs. Ctrl (A) and LH vs. NLH (B) comparisons. (C,D) Heatmap hierarchical clustering analysis of differentially expressed mRNA transcripts from individual animals (n = 4 per group) in LH vs. Ctrl (C) and LH vs. NLH (D) comparisons. (E) The numbers of regulated mRNA transcripts. Blue bars represent downregulated mRNAs, while red bars represent upregulated mRNAs. (F) Venn diagram showing overlap analysis of differentially expressed mRNAs using multiple comparisons: learned helpless vs. control (LH vs. Ctrl, blue), learned helpless vs. non-learned helpless (LH vs. NLH, yellow), Ctrl vs. Homecage (red) and Ctrl vs. NLH (green).