Table 2.

Schwann Cell-seeded biomaterial SCI studies.

SCI model	Biomaterial	Cell type	Outcome	References
Rat T8 transection	5 mm PAN/PVC and Matrigel (Category II)	Adult rat SC + BDNF and NT-3 infusion	Increased axonal growth up to biomaterial with NTFs	Xu et al., 1995a
Rat T8 transection	10 mm PAN/PVC and Matrigel (Category II)	Adult rat SC	Increased myelination of propriospinal and sensory axons within the scaffold but not exiting	Xu et al., 1995b
Rat T8 transection	8 mm PAN/PVC and Matrigel (Category II)	Adult rat SC	Increased myelination of propriospinal and sensory axons within the scaffold but not exiting	Xu et al., 1997
Rat T8 hemisection	5 mm PAN/PVC and Matrigel (Category II)	Adult rat SC	Increased myelination of propriospinal and sensory axons within the scaffold with some exiting	Xu et al., 1999
Rat C4 hemisection	2–3 mm PHB (Category II)	Adult rat SC	Some raphespinal and sensory axonal growth within the scaffold	Novikova et al., 2008
Rat C4 unilateral hemisection	2 mm alginate-based anisotropic capillary hydrogel (Category II and IV)	Adult rat GFP-SC	Serotonergic growth through and caudal to the biomaterial up to the 1 mm SC injection site	Liu et al., 2017
Rat T8 transection	4 mm PAN/PVC and fluid or pre-gelled Matrigel (Category I, II, III and IV)	Adult rat SC and OEC surrounding the lesion + ChABC	Increased SC myelination within the scaffold with increased BBB scores	Fouad et al., 2005
Rat T9-T10 hemisection	3 mm PAN/PVC (Categroy II)	Adult rat SC expressing GDNF	Enhanced SC remyelination of regenerating axons aligned with protruding astrocytic extensions	Deng et al., 2011
Rat T8 transection	4 mm PAN/PVC and fluid or pre-gelled Matrigel (Category I, II, and III)	Adult rat SC	Greater growth of virally traced brainstem-derived axons into and up to the caudal interface, formed synaptic junctions with the help of newly formed supportive astrocytic protrusions	Williams et al., 2015