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. 2018 Jan 11;11:119. doi: 10.3389/fncom.2017.00119

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Copyright © 2018 olde Scheper, Meredith, Mansvelder, van Pelt and van Ooyen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency dependence of two synapses, STDP curve plots with varying input frequencies for synapse 1 (blue) and synapse 2 (green). (A) Input frequencies of 10 and ~9.9 Hz (1 ms difference). (B) Input frequencies of 10 and ~9.8 Hz (2 ms difference). (C) Input frequencies of 10 and ~9.7 Hz (3 ms difference). (D) STDP curves of the first synapse receiving 10 Hz input drawn from (A–C), changes are solely due to the postsynaptic dynamics induced by the second synapse. From left to right, second synapse input is ~9.9, ~9.8, and ~9.7 Hz.