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. 2018 Jan 11;11:119. doi: 10.3389/fncom.2017.00119

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Copyright © 2018 olde Scheper, Meredith, Mansvelder, van Pelt and van Ooyen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition and the STDP curve. A single excitatory synapse and a single inhibitory synapse interact by modifying the postsynaptic activity. A postsynaptic action potential causes further adaptation. Shown is the STDP curve from the excitatory synapse. Left column (A–C) STDP curve of excitatory synapse driven by 5 Hz (200 ms) input with ~4.98 Hz (201 ms) inhibitory input. In (A,D) no further postsynaptic activity. In (B,E) an additional postsynaptic action potential at ~5.025 Hz (199 ms); in (C,F) the action potential has a frequency of ~4.95 Hz (202 ms).