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. 2018 Jan 11;8:1841. doi: 10.3389/fimmu.2017.01841

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Copyright © 2018 Danger, Royer, Reboulleau, Durand, Loy, Tissot, Lacoste, Roux, Reynaud-Gaubert, Gomez, Kessler, Mussot, Dromer, Brugière, Mornex, Guillemain, Dahan, Knoop, Botturi, Foureau, Pison, Koutsokera, Nicod, Brouard, Magnan and The COLT and SysCLAD Consortia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell lymphocyte kinase (BLK), POU2AF1, and TCL1A expression is downregulated by terminal respiratory failure. Expression of BLK, POU2AF1, and TCL1A in blood from non-transplanted patients with end-stage chronic respiratory diseases, displaying either cystic fibrosis (CF), pulmonary hypertension (PAH) (A), or idiopathic pulmonary fibrosis (IPF) (B) compared to healthy volunteers (HVs) (29, 30). The p values from Kruskal–Wallis tests with Dunn’s ad hoc pairwise comparisons or Mann–Whitney tests are indicated.